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Active research studies

Details of all our active research studies which are looking for volunteers, with more information about what each project entails and what kind of volunteers would be most suitable.

Epidemiology and prognosis in acute myocarditis

Myocarditis is a disease heart muscle caused by inflammation. This study aims to provide a contemporary, population-level assessment of the true clinical burden of myocarditis and how this may have changed over the last 20 years.


Active research studies

Safety and allegenicity of new vaccine for cat allergy

Study
An open label, safety and allergenicity Phase 0 study of a new hypoallergenic plant-derived cat dander vaccine in adult cat allergic subjects

IRAS no
1006294

Study contact information
Name: Gil Jimenez
Email: A.Eifan@rbht.nhs.uk

Principal investigator
Dr Guy Scadding

Click here for more information

Rhythm or rate control for CRT: the RHYTHMIC study

Study
Rhythm or rate control for CRT: the RHYTHMIC study   

IRAS no
265388

Study contact information
Name: Sara Salmi
Email: s.salmi@rbht.nhs.uk

Principal investigator
Dr Vias Markides

Click here for more information

MODESA

Study
Mitochondrial dysfunction of eosinophils as a driving force for its activation in eosinophilic severe asthma

IRAS no
293693

Study contact information
Name: Sally Meah
Email: S.Meah@rbht.nhs.uk

Principal investigator
Professor Fan Chung

Click here for more information


TRECOS

Study
A 12 week double-blind, multicentre, randomised, active-controlled, 2-arm, parallel-group clinical trial to evaluate the safety of CHF5993 pMDI 200/6/12.5 µg HFA-152a, compared to CHF5993 pMDI 200/6/12.5 µg HFA-134a, in subjects with asthma

IRAS no
1008211

Study contact information
Name: Dr David Watchorn
Email: d.watchorn@rbht.nhs.uk 

Principal investigator
Dr David Watchorn

Click here for more information


Nasal epithelial cells of healthy and asthmatic participants

Study
Study of the inflammatory properties of the nasal epithelial cells of healthy and asthmatic participants to define molecular phenotypes of severe asthma

IRAS no
336588

Study contact information
Name: Professor Fan Chung
Email: k.chung@rbht.nhs.uk

Principal investigator
Professor Fan Chung

Click here for more information


Pattern of chronic cough

Study
Measuring the pattern of cough in participants with chronic cough using Hyfe Cough monitor

IRAS no
329667

Study contact information
Name: Sally Meah
Email: sally.meah@imperial.ac.uk

Principal investigator
Professor Fan Chung

Click here for more information


TRECOS

Study
A 12 week double-blind, multicentre, randomised, active-controlled, 2-arm, parallel-group clinical trial to evaluate the safety of CHF5993 pMDI 200/6/12.5 µg HFA-152a, compared to CHF5993 pMDI 200/6/12.5 µg HFA-134a, in subjects with asthma

IRAS no
1008211

Study contact information
Name: Maria Fernandes
Email: m.fernandes@rbht.nhs.uk

Principal investigator
Dr David Watchorn

Click here for more information

ReCETT-AF

Study
Realistic Computational Electrophysiology Simulations for Targeted Treatment of Atrial Fibrillation

IRAS no
285221

Study contact information
Name: Dr Shouvik Haldar
Email: s.haldar@rbht.nhs.uk

Principal investigator
Dr Shouvik Haldar

Click here for more information


REMEDY-PILOT

Study
Reducing microvascular dysfunction in patients with angina, ischaemia and unobstructed coronary arteries – a pilot study (REMEDY-PILOT)

IRAS no
295523

Study contact information
Name: Carmen Chan
Email: l.chan2@rbht.nhs.uk

Principal investigator
Dr Ranil De Silva

Click here for more information


ANT-010

Study
A Phase 3, multicenter, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of abelacimab in high-risk patients with atrial fibrillation who have been deemed unsuitable for oral anticoagulation.

IRAS no
1007115

Study contact information
Name: Deirdre Flannery
Email: d.flannery@rbht.nhs.uk

Principal investigator
Dr John Foran

Click here for more information

Safety and efficacy of PC945 for the treatment of refractory invasive pulmonary aspergillosis

Study
A double-blind, randomized, placebo-controlled study to assess  the safety and efficacy of nebulized PC945 when added to  systemic antifungal therapy for the treatment of refractory  invasive pulmonary aspergillosis

IRAS no
1004474

Study contact information
Name: Dr Anna Reed
Email: a.reed@rbht.nhs.uk

Principal investigator
Dr Anna Reed

Click here for more information


GREAT-2 -GRemubamab ErAdication Trial

Study
GRemubamab ErAdication Trial (GREAT-2) A phase 2 trial of Gremubamab compared to placebo in participants with bronchiectasis and chronicPseudomonas aeruginosa infection

IRAS no
1005993

Study contact information
Name: Vladimir Domi
Email: v.domi@rbht.nhs.uk

Principal investigator
Professor Michael Loebinger

Click here for more information


EMILE

Study
Evaluation of the effect of Microbial dysbiosis upon anti-viral Immunity in bronchiEctasis

IRAS no
330984

Study contact information
Name: Dr Justin Garner
Email: j.garner@rbht.nhs.uk

Principal investigator
Dr Justin Garner

Click here for more information 


ERS-AMR-CRC

Study
Mapping antimicrobial resistance in chronic infectious lung disease: A European Respiratory Society Antimicrobial Resistance Clinical Research Collaborative

IRAS no
327747

Study contact information
Name: Dr Anand Shah
Email: a.shah2@rbht.nhs.uk

Principal investigator
Dr Anand Shah

Click here for more information


Impact of Chronic Pulmonary Aspergillosis (CPA) on health status and wellbeing

Study
Impact of Chronic Pulmonary Aspergillosis (CPA) on health status and wellbeing

IRAS no
327492

Study contact information
Name: Dr Anand Shah
Email: a.shah2@rbht.nhs.uk

Principal investigator
Dr Anand Shah

Click here for more information

Circulating cells in advanced cancer

Study
Sample collection study to explore CIrCulating tumour cells, cell free DNA and leucocytes with ImagesTReam analysis in patients with various cancers

IRAS no
198179

Study contact information
Name: Paula Rogers
Email: p.rogers@rbht.nhs.uk

Principal investigator
Paula Rogers

Click here for more information

There are currently no active studies 

UK lung volume reduction

Study
UK lung volume reduction - multicentre observational

IRAS no
190196

Study contact information
Name: Sara  Buttery
Email: S.Buttery@rbht.nhs.uk

Principal investigator
Dr Nicholas Hopkinson

Click here for more information


AIRFLOW-3

Study
A Multicenter, Randomised, Sham-controlled Study to Evaluate Safety and Efficacy After Treatment with the Nuvaira Lung Denervation System in Subjects with Chronic Obstructive Pulmonary Disease (COPD).

IRAS no
253708

Study contact information
Name: Dr Francesca Conway
Email: f.conway@rbht.nhs.uk

Principal investigator
Professor Pallav Shah 

Click here for more information


The WHAM Study

Study
Randomised controlled feasibility study of Maintaining the benefits of Pulmonary Rehabilitation with Harmonies and Melodies via Singing for Lung Health.

IRAS no
293580

Study contact information
Name: Peter Jung
Email: p.jung@rbht.nhs.uk

Principal investigator
Dr Adam Lewis

Click here for more information


The ON-PACE trial

Study
Dietary nitrate supplementation to enhance daily physical activity in hypoxic COPD: a randomised controlled trial   

IRAS no
315107

Study contact information
Name: Alexis Perkins
Email: a.perkins@rbht.nhs.uk

Principal investigator
Dr Nicholas Hopkinson

Click here for more information


SPRAY-CB

Study
A Sham Controlled Prospective Randomized Clinical Trial of the RejuvenAir System for the Treatment of Moderate to Severe Chronic Obstructive Pulmonary Disease with Chronic Bronchitis

IRAS no
304514

Study contact information
Name: Professor Pallav Shah
Email: p.shah@rbht.nhs.uk

Principal investigator
Professor Pallav Shah

Click here for more information


AI in PRImary Care spirometry for diagnosis of Lung Disease (APRIL)

Study
Real-world evaluation of an Artificial-Intelligence support software (ArtiQ.Spiro) in Primary Care spirometry pathways for the detection of Lung Disease.

IRAS no
324175

Study contact information
Name: Dr William Man
Email: w.man@rbht.nhs.uk

Principal investigator
Dr William Man

Click here for more information


BREATH-2

Study
Bronchoscopic Release of Air Trapped in Hyperinflated Emphysematous Lung

IRAS no
326148

Study contact information
Name: Dr Christopher Orton
Email: c.orton@rbht.nhs.uk

Principal investigator
Professor Pallav Shah

Click here for more information


The Hyper-COPD Study

Study
Breathing Vigilance in a COPD population with hyperinflation

IRAS no
321477

Study contact information
Name: Dr Justin Garner
Email: j.garner@rbht.nhs.uk

Principal investigator
Dr Justin Garner

Click here for more information


ATHLOSS

Study
A Double-Blind, Multicentre, Randomized, Three-Period, Three-Treatment, Cross-Over Study to Evaluate the Effect of BGF MDI, BFF MDI, and Placebo MDI on Exercise Parameters in Participants with Chronic Obstructive Pulmonary Disease

IRAS no
1007637

Study contact information
Name: Camilla Goulsbra
Email: c.goulsbra@rbht.nhs.uk

Principal investigator
Professor Michael Polkey

Click here for more information


Ryme Medical TLD Pilot Study

Study
Targeted lung denervation (TLD) with the Ryme Medical Lung Denervation System in patients with chronic obstructive pulmonary disease (COPD)

IRAS no
337994

Study contact information
Name: Dr Anand Tana
Email: a.tana@rbht.nhs.uk

Principal investigator
Professor Pallav Shah

Click here for more information

FADE UK

Study
Analysing Fungal Disease Epidemiology in the UK

IRAS no
300045

Study contact information
Name: Dr Anand Shah
Email: A.Shah2@rbht.nhs.uk

Principal investigator
Dr Anand Shah

Clinical Artificial Intelligence Fetal Echocardiography (CAIFE)

Study
Development of Clinical Artificial Intelligence Models in Fetal Echocardiography for the Detection of Congenital Heart Defects

IRAS no
317510

Study contact information
Name: Julene Carvalho
Email: j.carvalho@rbht.nhs.uk

Principal investigator
Dr Olga Patey

Click here for more information

CF start

Study
The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial (CF START); a randomised registry trial to assess the safety and efficacy of flucloxacillin as a longterm prophylaxis agent for infants with CF

IRAS no
211995

Study contact information
Name: Dr Siobhan Carr
Email: s.carr@rbht.nhs.uk

Principal investigator
Dr Siobhan Carr

Click here for more information


Targeting Immunotherapy for Fungal Infection in Cystic Fibrosis

Study
TrIFIC: Targeting Immunotherapy for Fungal Infection in Cystic Fibrosis

IRAS no
270828

Study contact information
Name: Maria Nunez
Email: M.Nunez@rbht.nhs.uk

Principal investigator
Dr James Darius-Armstrong

Click here for more information


Clinical Outcomes With Novel Modifier Therapy Combination (RECOVER)

Study
Real World Clinical Outcomes With Novel Modifier Therapy Combinations in People with CF

IRAS no
296928

Study contact information
Name: Clare Saunders
Email:  c.saunders2@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


Clinimetric properties of Oxygen-Enhanced MRI

Study
Determining the clinimetric properties of structural and functional outputs of oxygen-enhanced magnetic resonance imaging in children and adults with cystic fibrosis (CF) and chronic suppurative lung disease (CSLD)

IRAS no
294686

Study contact information
Name: Cristopher Short
Email: C.Short@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA in Cystic Fibrosis Subjects

Study
A Phase 3 Open-label Study Evaluating the Long‑term Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor Triple Combination Therapy in Cystic Fibrosis Subjects 2 Years and Older

IRAS no
1004766

Study contact information
Name: Jessie Matthews
Email: j.matthews@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


A Phase 3 Study of VX-121 Combination Therapy in Subjects With Cystic Fibrosis Heterozygous

Study
 A Phase 3, Randomized, Double-blind, Controlled Study Evaluating the Efficacy and Safety of VX-121 Combination Therapy in Subjects With Cystic Fibrosis Who Are Heterozygous for F508del and a Minimal Function Mutation (F/MF)

IRAS no
1003950

Study contact information
Name: Jessie Matthews
Email: j.matthews@rbht.nhs.uk

Principal investigator
Dr Nicholas Simmonds

Click here for more information


A Phase 1/2 Dose-escalation Study Evaluating the  Safety, Tolerability, and Efficacy of VX-522 in  Subjects 18 Years of Age and Older With Cystic  Fibrosis and a CFTR Genotype Not Responsive to  CFTR Modulator Therapy

Study
A Phase 1/2 Dose-escalation Study Evaluating the  Safety, Tolerability, and Efficacy of VX-522 in  Subjects 18 Years of Age and Older With Cystic  Fibrosis and a CFTR Genotype Not Responsive to  CFTR Modulator Therapy

IRAS no
1005878

Study contact information
Name: Clare Saunders
Email: c.saunders2@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


Skyline Open label Extension - VX20-121-104

Study
A Phase 3, Open-label Study Evaluating the Long-term Safety and Efficacy of VX-121 Combination Therapy in Subjects With Cystic Fibrosis

IRAS no
1005889

Study contact information
Name: Dr Nicholas Simmonds
Email: n.simmonds@rbht.nhs.uk

Principal investigator
Dr Nicholas Simmonds

Click here for more information


A Randomised, Double-Blind, Placebo Controlled, Two-Part Study to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of a Repeat Dose of Inhaled ETD001 in People with Cystic Fibrosis
 

Study
A Randomised, Double-Blind, Placebo Controlled, Two-Part Study to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of a Repeat Dose of Inhaled ETD001 in People with Cystic Fibrosis

IRAS no
1008079

Study contact information
Name: Yasmine Needham
Email: y.needham@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


CFTR c.3874-4522A>G's impact on cystic fibrosis severity
 

Study
Investigating the possible association between expression of the CFTR: c.3874-4522A>G deep intronic variant and phenotype severity in patients with Cystic Fibrosis 

IRAS no
335624

Study contact information
Name: Anna Lockhart
Email: a.lockhart@rbht.nhs.uk

Principal investigator
Dr Deborah Morris-Rosendahl

Click here for more information


ENHANCE
 

Study
Establishing Natural History in an Advanced New CF Care Era

IRAS no
332109

Study contact information
Name: Clare Saunders
Email: c.saunders2@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


YOGA-CF
 

Study
Yoga Outcomes Get Assessed in Cystic Fibrosis (YOGA-CF)

IRAS no
303898

Study contact information
Name: Gemma Stanford
Email: g.stanford@rbht.nhs.uk

Principal investigator
Gemma Stanford

Click here for more information


CHOICES
 

Study
A Phase IIb, Multicentre, Randomised, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Efficacy and Safety of irocaftor/Posenacaftor/Nesolicaftor in Subjects with Cystic Fibrosis Aged 18 Years or Older (CHOICES)

IRAS no
1005882

Study contact information
Name: Yasmine Needham
Email: y.needham@rbht.nhs.uk

Principal investigator
Dr Nicholas Simmonds

Click here for more information

Natural History Dilated Cardiomyopathy Associated with BAG3 Mutations

Study
A prospective multinational study of the natural history of participants with BAG3 mutation associated dilated cardiomyopathy

IRAS no
321187

Study contact information
Name: Teresa Pfyl
Email: m.pfyl@rbht.nhs.uk

Principal investigator
Dr Antonis Pantazis

Click here for more information


The SMARTER-CM Study

Study
Genetics, Imaging And Artificial Intelligence for Precision Care in Cardiomyopathy

IRAS no
313058

Study contact information
Name: Dr Upasana Tayal
Email: u.tayal@rbht.nhs.uk

Principal investigator
Dr Upasana Tayal

Click here for more information

Go DCM

Study
Defining the genetics, biomarkers and outcomes for dilated cardiomyopathy: a prospective multi-centre observational study

IRAS no
237880

Study contact information
Name: Teijo Palovaara
Email: T.Palovaara@rbht.nhs.uk

Principal investigator
Dr James Ware

Click here for more information


HEART - ACS V1.0

Study
The HarEfield Acute MyocaRdial InfarcTion Cohort

IRAS no
259087

Study contact information
Name: Laura Barker
Email: L.Barker2@rbht.nhs.uk

Principal investigator
Dr Miles Dalby

Click here for more information


Epidemiology and Prognosis in Acute Myocarditis 

Study
Epidemiological trends and outcomes of hospital admissions for acute myocarditis and dilated cardiomyopathy in the National Health Service of England from 1998 onwards.

IGARD reference number
DARS-NIC-144568-D7G6V

Study contact information
Name: Amrit Lota
Email: A.Lota@rbht.nhs.uk

Principal investigator
Professor Sanjay Prasad

Click here for more information


A possible new treatment for elevated Lp(a) in CVD - HORIZON

Study
A randomised double-blind, placebo-controlled, multicenter trial assessing the impact of lipoprotein (a) lowering with TQJ230 on major cardiovascular events in patients with established cardiovascular disease (CVD).

IRAS no
267092

Study contact information
Name: Alkida Bucaj
Email: A.Bucaj@rbht.nhs.uk

Principal investigator
Professor Mahmoud Barbir

Click here for more information


Olpasiran trials of Cardiovascular Events And LipoproteiN(a) reduction – Outcomes trial

Study
A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing the Impact of Olpasiran on Major Cardiovascular Events in Patients with Atherosclerotic Cardiovascular Disease and Elevated Lipoprotein (a)

IRAS no
1006924

Study contact information
Name: Sankari Nagarajan
Email: s.nagarajan@rbht.nhs.uk

Principal investigator
Dr Tina Khan

Click here for more information


Examining the effect of mitochondrial oxidative stress in DCM

Study
Examining the role of mitochondrial oxidative stress in dilated cardiomyopathy

IRAS no
286376

Study contact information
Name: Katherine Smith
Email: k.smith@rbht.nhs.uk

Principal investigator
Dr Brian Halliday

Click here for more information


CE-MARC 3

Study
A pragmatic approach to the investigation of stable chest pain: a UK, multi-centre, randomised trial to improve patient experience, outcomes and NHS cost efficiency

IRAS no
302218

Study contact information
Name: Dr Chiara Bucciarelli-Ducchi
Email: c.bucciarelli-ducci@rbht.nhs.uk

Principal investigator
Dr Ciara Bucciarelli-Ducchi

Click here for more information


VICTORION REAL v01

Study
An international prospective Real-world study to evaluate the Effectiveness and Adherence of incLisiran plus standard of care lipid-lowering therapy compared to standard of care therapy alone in patients with primary hypercholesterolemia or mixed dyslipidemia

IRAS no
317604

Study contact information
Name: Susshmitha Ramesh
Email: s.ramesh2@rbht.nhs.uk

Principal investigator
Dr Barbir Mahmoud

Click here for more information


BRITISH: Using CMR scar as risk indication tool in NICM and severe LVSD

Study
Using cardiovascular magnetic resonance identified scar as the Benchmark Risk Indication Tool for Implantable cardioverter defibrillators in patients with Non-Ischemic Cardiovascular and Severe systolic Heart failure

IRAS no
280862

Study contact information
Name: Annashyl West
Email: a.west@rbht.nhs.uk

Principal investigator
Professor Sanjay Prasad

Click here for more information


TRED-HF2

Study
A randomised trial examining therapy to maintain remission in dilated cardiomyopathy

IRAS no
1006543

Study contact information
Name: Saad Javed
Email: s.javed@rbht.nhs.uk 

Principal investigator
Dr Brian Halliday

Click here for more information


HER-SAFE

Study
Randomised Control Trial for the Safety of Withdrawal of Pharmacological Treatment for Recovered HER2 Targeted Therapy Related Cardiac Dysfunction

IRAS no
312432

Study contact information
Name: Dr Alexander Lyon
Email: a.lyon@rbht.nhs.uk

Principal investigator
Dr Alexander Lyon

Click here for more information


Low QRS voltages in young healthy individuals and athletes

Study
The prevalence and significance of low QRS voltages in young healthy individuals and athletes

IRAS no
283055

Study contact information
Name: Dr Nirmitha Jayaratne
Email: n.jayaratne@rbht.nhs.uk

Principal investigator
Dr Sabiha Gati

Click here for more information


TN-401-0011

Study
Seroprevalence Study of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV) in Patients with Plakophilin 2 (PKP2)-associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)

IRAS no
323224

Study contact information
Name: Teresa Pfyl
Email: m.pfyl@rbht.nhs.uk

Principal investigator
Dr Antonis Pantazis

Click here for more information


Cardiac cachexia in advanced heart failure – a prospective cohort study investigating prevalence and outcome

Study
Cardiac cachexia in advanced heart failure – a prospective cohort study investigating prevalence and outcome

IRAS no
334613

Study contact information
Name: Dr Mansimran Singh Dulay
Email: m.singhdulay@rbht.nhs.uk

Principal investigator
Dr Owais Dar

Click here for more information


MAPLE-HCM

Study
A Phase 3, Multi-center, Randomized, Double-blind Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol in Adults with Symptomatic Obstructive Hypertrophic Cardiomyopathy

IRAS no
1007788

Study contact information
Name: Dr Antonis Pantazis
Email: a.pantazis@rbht.nhs.uk

Principal investigator
Dr Antonis Pantazis

Click here for more information


Euro-CRAFT Registry

Study
Prospective evaluation of the impact of coronary themodilution on clinical outcomes in chronic coronary syndromes

IRAS no
315345

Study contact information
Name: Maria Teresa Pfyl
Email: m.pfyl@rbht.nhs.uk

Principal investigator
Dr Ranil De Silva

Click here for more information


BalanceD-HF

Study
A Phase III, Randomised, Double-blind Study to Evaluate the Effect of Balcinrenone/Dapagliflozin, Compared to Dapagliflozin, on the Risk of Heart Failure Events and Cardiovascular Death in Patients with Heart Failure and Impaired Kidney Function

IRAS no
1009392

Study contact information
Name: Melinda Holden
Email: m.holden@rbht.nhs.uk

Principal investigator
Dr Owais Dar

Click here for more information


The Acorai Study

Study
A single-site prospective observational study to assess the value of the data harvested by the Acorai intracardiac pressure monitoring (ICPM) system in predicting outcomes in patients ready for discharge from hospital following an admission with decompens

IRAS no
334837

Study contact information
Name: Ramey Assaf
Email: r.assaf@rbht.nhs.uk

Principal investigator
Dr Owais Dar

Click here for more information

Progressive Fibrosing Lung Disease (PROFOUND)

Study
Identifying progressive fibrosing lung disease: a study of genetic and environmental interactions: an observational cohort study.

IRAS no
279948

Study contact information
Name: Jessica Wallen
Email: j.wallen@rbht.nhs.uk

Principal investigator
Dr Philip Molyneaux

Click here for more information


A Phase 2 study of RXC007 in patients with IPF

Study
A Multi-Cohort, Randomized, Placebo-Controlled Phase 2a Study to Assess the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of Ascending Doses of RXC007 in Patients with Idiopathic Pulmonary Fibrosis.

IRAS no
1005138

Study contact information
Name: Abigail Watson
Email: a.watson2@rbht.nhs.uk

Principal investigator
Dr Philip Molyneaux

Click here for more information


A Study to Investigate MBS2320 Patients with IPF

Study
A Randomised, Double-Blind, Placebo-Controlled, Phase 2 Study to Investigate the Efficacy and Safety of MBS2320 in Patients With Idiopathic Pulmonary Fibrosis (IPF)

IRAS no
1007976

Study contact information
Name: Maria Fernandes
Email: m.fernandes@rbht.nhs.uk

Principal investigator
Professor Philip Molyneaux

Click here for more information


NAL03-202  - Trevi Therapeutics, Inc. - Idiopathic Pulmonary Fibrosis - 4318/0010

Study
A Randomised, Double-Blind, Placebo-Controlled, Parallel, 4-Arm Dose Ranging Study of the Safety and Efficacy of NAL ER Tablets for the Treatment of Cough in Idiopathic Pulmonary Fibrosis (IPF) 

IRAS no
1008035

Study contact information
Name: Abigail Watson
Email: a.watson2@rbht.nhs.uk

Principal investigator
Professor Philip Molyneaux

Click here for more information


Efzo-Fit Study

Study
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Intravenous Efzofitimod in Patients with Pulmonary Sarcoidosis

IRAS no
1006104

Study contact information
Name: Abigail Watson
Email: a.watson2@rbht.nhs.uk

Principal investigator
Dr Vasilis Kouranos

Click here for more information


IM027-068

Study
A multicenter, randomized, double-blind, placebo-controlled, Phase 3 Study to evaluate the efficacy, safety, and tolerability of BMS-986278 in participants with idiopathic pulmonary fibrosis (IPF)

IRAS no
1008043

Study contact information
Name: Deirdre Flannery
Email: d.flannery@rbht.nhs.uk

Principal investigator
Professor Philip Molyneaux

Click here for more information


Treatment of idiopathic pulmonary fibrosis (IPF)

Study
A randomised, double-blind, dose-ranging, placebo-controlled study to evaluate the efficacy and safety of PLN-74809 bexotegrast) for the treatment of idiopathic pulmonary fibrosis (BEACON)

IRAS no
1008893

Study contact information
Name: Abigail Hamilton
Email: a.hamilton@rbht.nhs.uk

Principal investigator
Professor Philip Molyneaux

Click here for more information

There are currently no active studies 

Transmural myocardial perfusion with hypertension, HCM and HCM phenocopies with CMR

Study
The measurement of transmural myocardial perfusion in normal subjects and patients with hypertension, hypertrophic cardiomyopathy (HCM) and HCM phenocopies with Cardiovascular Magnetic Resonance (CMR)

IRAS no
171258

Study contact information
Name: Brian Halliday
Email: B.Halliday@rbht.nhs.uk

Principal investigator
Dr Sanjay Prasad


CY 6022

Study
An open-label study of CK-3773274 for patients with Symptomatic Hypertrophic Cardiomyopathy (HCM)

IRAS no
1005788

Study contact information
Name: Teresa Pfyl
Email: m.pfyl@rbht.nhs.uk

Principal investigator
Dr Antonis Pantazis

Click here for more information


Mavacamten in non-obstructive HCM

Study
A randomised, double-blind, placebo-controlled clinical study to evaluate mavacamten in adults with symptomatic non-obstructive hypertrophic cardiomyopathy

IRAS no
1006306

Study contact information
Name: Teresa Pfyl
Email: m.pfyl@rbht.nhs.uk

Principal investigator
Dr Brian Halliday

Click here for more information


CY 6033 - Cytokinetics - Symptomatic Non-obstructive Hypertrophic Cardiomyopathy - 0771/0069

Study
A phase 3, multi-center, randomized, double-blind trial to evaluate the efficacy and safety of aficamten compared to placebo in adults with symptomatic non-obstructive hypertrophic cardiomyopathy

IRAS no
1008323

Study contact information
Name: Teresa Pfyl
Email: m.pfyl@rbht.nhs.uk

Principal investigator
Dr Antonis Pantazis

Click here for more information

GenOMICC

Study
Genetics of susceptibility and mortality in critical care (GenOMICC)

IRAS no
269326

Study contact information
Name: Dr Brijesh Patel
Email: B.Patel4@rbht.nhs.uk

Principal investigator
Dr Brijesh Patel

Click here for more information


The HITEC study

Study
Haemostasis and Immunothrombosis in Extracorporeal Circuits

IRAS no
294477

Study contact information
Name: Dr Teresa Lee
Email: t.lee@rbht.nhs.uk

Principal investigator
Dr Brijesh Patel

Click here for more information


HERACLES

Study
HEmodynamic effects of Reducing lv Afterload with impella or intra-aortic balloon CounterpuLsation during veno-arterial Extracorporeal membrane oxygenation in cardiogenic Shock

IRAS no
300145

Study contact information
Name: Professor Susanna Price
Email: s.price@rbht.nhs.uk

Principal investigator
Professor Susanna Price & Dr Vasileios Panoulas

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GOlDilOCS: Genomic determinants of outcome in cardiogenic shock

Study
Prospective observational study investigating genomic determinants of outcome from cardiogenic shock   

IRAS no
290406

Study contact information
Name: Keir Stirrat
Email: k.stirrat@rbht.nhs.uk

Principal investigator
Dr Brijesh Patel

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Indications, efficacy and safety profiles of dual treatment with Levosimendan and Sildenafil in critically ill adult patients

Study
Indications, efficacy and safety profiles of dual treatment with Levosimendan and Sildenafil in critically ill adult patients

IRAS no
326729

Study contact information
Name: Dr Sundeep Kaul
Email: s.kaul@rbht.nhs.uk

Principal investigator
Dr Sundeep Kaul

I-FILE

Study
An international patient-led registry in fibrotic interstitial lung diseases using eHealth technology

IRAS no
291393

Study contact information
Name: Victor Jardim
Email: v.jardim@rbht.nhs.uk

Principal investigator
Dr Philip Molyneaux

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ILD-DNA   

Study
Interstitial Lung Disease DNA Study

IRAS no
316318

Study contact information
Name: Mr Philip Molyneaux
Email: p.molyneaux@rbht.nhs.uk

Principal investigator
Mr Philip Molyneaux

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1305-0023: Phase III PoCC pivotal trial #1 BI 1015550 - PDE4 inhibitor in AF experienced PF-ILD

Study
Phase III PoCC pivotal trial #1 BI 1015550 - PDE4 inhibitor in AF experienced PF-ILD

IRAS no
1006258

Study contact information
Name: Maria Nunez
Email: m.nunez@rbht.nhs.uk

Principal investigator
Mr Philip Molyneaux

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ILD: Health Outcomes in Remote Digital Monitoring versus Usual Care

Study
Comparison of health outcomes in a remote monitoring programme versus usual care in Interstitial Lung Disease

IRAS no
301636

Study contact information
Name: Abigail Watson
Email: a.watson2@rbht.nhs.uk

Principal investigator
Professor Philip Molyneaux

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ALOFT-PPF

Study
A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 3 Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants with Progressive Pulmonary Fibrosis

IRAS no
1008044

Study contact information
Name: Abigail Hamilton
Email: a.hamilton@rbht.nhs.uk

Principal investigator
Professor Philip Molyneaux

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Tracking no small cell lung cancer evaluation

Study
Tracking non small cell lung cancer evolution through therapy (Rx)

IRAS no
138871

Study contact information
Name: Paulo De Sousa
Email: P.DeSousa@rbht.nhs.uk

Principal investigator
Mr Eric Lim

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Lung nodule Imaging Biobank for Radiomics and AI research (LIBRA)

Study
Lung nodule Imaging Biobank for Radiomics and AI research (LIBRA)

IRAS no
274775

Study contact information
Name: Professor Anand Devaraj
Email: A.Devaraj@rbht.nhs.uk

Principal investigator
Professor Anand Devaraj

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AI-SONAR

Study
AI & radiomics for Stratification Of lung Nodules After Radically treated cancer

IRAS no
300424

Study contact information
Name: Professor Anand Devaraj
Email: A.Devaraj@rbht.nhs.uk

Principal investigator
Professor Anand Devaraj


ADAURA2

Study
Phase III, Double-blind, Randomized, Placebo-Controlled, International Study to assess the Efficacy and Safety of Adjuvant Osimertinib versus Placebo in Patients with EGFR mutation-positive Stage IA2-IA3 Non-small Cell Lung Cancer, following Complete Tumoour removal.

IRAS no
1004224

Study contact information
Name: Paulo De Sousa
Email: P.DeSousa@rbht.nhs.uk

Principal investigator 
Professor Eric Lim

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F4S-2

Study
Fit 4 Surgery 2: A randomised controlled trial to investigate an App-based, motivation-theory grounded, personalised, comprehensive, prehabilitation programme in addition to usual care versus usual care alone to enhance recovery of physical function

IRAS no
317416

Study contact information
Name: Paulo De Sousa
Email: P.DeSousa@rbht.nhs.uk

Principal investigator 
Professor Eric Lim

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There are currently no active studies 

There are currently no active studies 

Treating severe paediatric asthma; the TREAT trial

Study
Treating severe paediatric asthma; a randomised controlled trial of mepolizumab and omalizumab (TREAT trial)

IRAS no
252084

Study contact information
Name: Professor Sejal Saglani
Email: S.Saglani@rbht.nhs.uk

Principal investigator
Professor Sejal Saglani

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ICONIK

Study
Inherited Cardiac cONditions In Kids Understanding the Genetics and Outcomes of Paediatric Inherited Cardiac Conditions

IRAS no
288514

Study contact information
Name: Dr Andres Rico-Armada
Email: a.rico-armada@rbht.nhs.uk

Principal investigator
Dr Andres Rico-Armada

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GASTRIC-PICU

Study
A randomised controlled trial of no routine gastric residual monitoring to guide enteral feeding in paediatric intensive care units

IRAS no
322370

Study contact information
Name: Laura Tous Sampol
Email: l.toussampol@rbht.nhs.uk

Principal investigator
Dr Justin Wang


Paediatric FH Register Study

Study
Estimating appropriate lipid lowering management in the United Kingdom Paediatric Familial Hypercholesterolaemia Register

IRAS no
324246

Study contact information
Name: Emma Neves
Email: e.neves@rbht.nhs.uk

Principal investigator
Lorraine Priestley-Barnham   

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VX22-445-122

Study
A Phase 3, Open-label Study Evaluating the Pharmacokinetics, Safety, and Tolerability of Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis Subjects 12 to Less Than 24 Months of Age

IRAS no
1007349

Study contact information
Name:  Clare Saunders
Email: c.saunders2@rbht.nhs.uk

Principal investigator
Professor Jane Davies

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Natural History Study in Pediatric Patients with MYBPC3

Study
A Prospective and Retrospective Registry and Biomarker Study to Evaluate the Natural History of Pediatric Patients with Cardiomyopathy due to MYBPC3 Mutations

IRAS no
304240

Study contact information
Name: Annashyl West
Email: a.west@rbht.nhs.uk

Principal investigator
Dr Janice Till

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PDA study v 1.2

Study
A multicenter, international, prospective and retrospective, post marketing clinical follow-up study to evaluate the efficacy and safety of the occlutech patent ductus arteriosus occluder (the occlutech pda occluder) in patient with patent ductus arterios

IRAS no
318495

Study contact information
Name: Karl Evangelista
Email: k.evangelista@rbht.nhs.uk

Principal investigator
Professor Alain Fraisse

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VICTORION-PEDS-OLE

Study
An open-label, single arm, multicenter extension study to evaluate long-term safety and tolerability of inclisiran in participants with heterozygous or homozygous familial hypercholesterolemia who have completed the adolescent ORION-16 or ORION-13 studies

IRAS no
1007316

Study contact information
Name: Sankari Nagarajan
Email: s.nagarajan@rbht.nhs.uk

Principal investigator
Dr Mahmoud Barbir

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ARDS in Children and ECMO strategies impact on Neuro-Development

Study
ARDS in Children and ECMO initiation strategies impact on Neuro-Development (ASCEND)

IRAS no
292537

Study contact information
Name: Justin Wang
Email: q.wang@rbht.nhs.uk 

Principal investigator
Angela Aramburo

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Machine learning to diagnose PCD

Study
Improving Primary Ciliary Dyskinesia diagnosis using artificial intelligence

IRAS no
259067

Study contact information
Name: Thomas Burgoyne
Email: T.Burgoyne@rbht.nhs.uk

Principal investigator
Professor Claire Hogg

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RCT1100-101

Study
A Phase 1, Randomized, Double-Blind, Placebo Controlled, Single Ascending Dose Study in Healthy Adult Participants and Open-Label Single Ascending Dose Study in Adults with Primary Ciliary Dyskinesia Caused by Pathogenic Mutations in the DNAI1 Gene

IRAS no
1008307

Study contact information
Name: Arvin Fernando
Email: a.fernando@rbht.nhs.uk 

Principal investigator
Professor Michael Loebinger

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Acceleron

Study
An Open-Label Long-term Follow-up Study to Evaluate the Effects of Sotatercept When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy for the Treatment of PAH

IRAS no
1003791

Study contact information
Name: Joy Pinguel
Email: a.pinguel@rbht.nhs.uk

Principal investigator
 Dr Stephen John Wort

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Hyperion

Study
A Phase 3, Randomized, Double-blind, Placebo-controlled study to Evaluate Sotatercept When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy in Newly Diagnosed Intermediate-and High-risk PAH Patients

IRAS no
1003773

Study contact information
Name: Joy Pinguel
Email: a.pinguel@rbht.nhs.uk

Principal investigator
Dr Colm McCabe

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A011-14

Study
A Phase 3, Randomized, Double-Blind, PlaceboControlled Study to Evaluate Sotatercept When Added to Maximum Tolerated Background Therapy in Participants With Pulmonary Arterial Hypertension (PAH) World Health Organization (WHO) Functional Class (FC) III or FC IV at High Risk of Mortality.

IRAS no
1004073

Study contact information
Name: Joy Pinguel
Email: a.pinguel@rbht.nhs.uk

Principal investigator
Dr Stephen John Wort

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IMPAHCT Phase 2b/3 Study of AV-101 for Pulmonary Arterial Hypertension

Study
A Phase 2b/3, Randomized, Double-Blind, Placebo-Controlled, 24-Week Dose Ranging and Confirmatory Study to Evaluate the Safety and Efficacy of AV-101 in Patients with Pulmonary Arterial Hypertension (PAH)

IRAS no
299052

Study contact information
Name: Victor Jardim
Email: v.jardim@rbht.nhs.uk

Principal investigator
Dr Colm McCabe

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CLTP002A12201 PAH

Study
A randomized, participant- and investigator-blinded, placebo-controlled study to investigate efficacy, safety and tolerability of LTP001 in participants with pulmonary arterial hypertension

IRAS no
1004298

Study contact information
Name: Apple Joy Pinguel
Email: a.pinguel@rbht.nhs.uk

Principal investigator
Dr John Wort Stephen

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Real-World Comparative Effectiveness Study of TYVASO Inhaled Treprostinil) in the Treatment of PH-ILD

Study
Real-World Comparative Effectiveness Study of TYVASO Inhaled Treprostinil) in the Treatment of PH-ILD

IRAS no
335576

Study contact information
Name: Victor Jardim
Email: v.jardim@rbht.nhs.uk

Principal investigator
Dr Laura Price


Re-PHIRE

Study
A Phase IIb Randomised, Double-blind, Placebo-controlled, Multi-centre, Dose-ranging Study of AZD3427 in Participants with Heart Failure and Pulmonary Hypertension due to Left Heart Disease (WHO Group 2)

IRAS no
1007304

Study contact information
Name: Keir Stirrat
Email: k.stirrat@rbht.nhs.uk

Principal investigator
Dr Ali Vazir

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GB002-3101 Efficacy and Safety of Seralutinib in Adult Subjects with PAH

Study
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Oral Inhalation of Seralutinib for the Treatment of Pulmonary Arterial Hypertension (PAH)

IRAS no
1007953

Study contact information
Name: Apple Joy Pinguel 
Email: a.pinguel@rbht.nhs.uk

Principal investigator
Dr Colm McCabe

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Effectiveness of inhaled treprostinil versus standard of care for the treatment of pulmonary hypertension associated with interstitial lung disease

Study
Effectiveness of inhaled treprostinil versus standard of care for the treatment of pulmonary hypertension associated with interstitial lung disease: A propensity score-matched study of the INCREASE trial and registry data from the United Kingdom

IRAS no
340955

Study contact information
Name: Ifan Jenkin
Email: i.jenkin@rbht.nhs.uk

Principal investigator
Dr Laura Price

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PHoenix

Study
A multicentre randomised cross-over trial of disease specific therapy in patients with Pulmonary Arterial Hypertension (PAH) implanted with pulmonary artery pressure and cardiac rhythm monitoring devices (CardioMEMS/Confirm Rx)

IRAS no
325120

Study contact information
Name: Meriel Woodruff
Email: m.woodruff@rbht.nhs.uk

Principal investigator
Dr Stephen John Wort

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KER-012

Study
A randomised, phase 2, double-blind, placebo-controlled study to investigate the safety and efficacy of KER-012 in combination with background therapy in adult participants with Pulmonary Arterial Hypertension

IRAS no
1007494

Study contact information
Name: Apple Joy Pinguel 
Email: a.pinguel@rbht.nhs.uk

Principal investigator
Dr Laura Price

Click here for more information

There are currently no active studies 

The role of conventional and advanced imaging modalities in formulating an optimal risk stratification strategy in patients with suspected cardiac sarcoidosis

Study
The role of conventional and advanced imaging modalities in formulating an optimal risk stratification strategy in patients with suspected cardiac sarcoidosis

IRAS no
310314

Study contact information
Name: Raheel Ahmed
Email: r.ahmed2@rbht.nhs.uk

Principal investigator
Dr Vasilis Kouranos

Click here for more information

There are currently no active studies 

Avr Thrombosis OutcoMe study (ATOM)

Study
Can thrombosis and fibrinolysis markers in patients undergoing aortic valve replacement predict outcome

IRAS no
259805

Study contact information
Name: Michelle Rackham
Email: M.Rackham@rbht.nhs.uk

Principal investigator
Dr Vasileios Panoulas

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RESOLVE MR

Study
Real World Study of the Tendyne™ Mitral Valve System to Treat Mitral Regurgitation (Tendyne™ PMCF Study)

IRAS no
304570

Study contact information
Name: Anelise Catelan Zborowski
Email: a.catelanzborowski@rbht.nhs.uk

Principal investigator
Dr Alison Mary Duncan

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STRESS-MR - Haemodynamics of Mitral Regurgitation Reduction

Study
Comparative STudy chaRacterising the physiological changEs induced by Surgical and tranScatheter Mitral Regurgitation reduction - STRESS-MR

IRAS no
293585

Study contact information
Name: Dr Robert Smith
Email: r.smith@rbht.nhs.uk

Principal investigator
Dr Robert Smith

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Acorai MLG study

Study
A Multi-Site Observational Clinical Investigation to Collect Non-invasive Sensor Data During a Right Heart Catheterization and Train Machine Learning Models to Estimate Intracardiac Hemodynamic Parameters

IRAS no
328221

Study contact information
Name: Dr Owais Dar
Email: o.dar@rbht.nhs.uk

Principal investigator
Dr Owais Dar

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APOLLO-EU study

Study
Transcatheter Mitral Valve Replacement with the Medtronic IntrepidTM TMVR Transfemoral System in patients with severe symptomatic mitral regurgitation

IRAS no
319225

Study contact information
Name: Abigail Watson
Email: a.watson2@rbht.nhs.uk

Principal investigator
Dr Alison Mary Duncan

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BigpAK-2

Study
Biomarker- guided intervention to prevent acute kidney injury after major non-cardiac surgery - the prospective multicenter randomized controlled interventional trial

IRAS no
299561

Study contact information
Name: Alessandra Verzelloni
Email: a.verzellonisef@rbht.nhs.uk

Principal investigator
Dr Nandor Marczin

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STAR Registry

Study
Safe and Timely Antithrombotic Removal (STAR REGISTRY): International registry on the use of CytoSorb for removal of antithrombotic agents in the acute hospital setting.

IRAS no
301571

Study contact information
Name: Jovile Kazileviciute
Email: j.kazileviciute@rbht.nhs.uk

Principal investigator
Dr Nandor Marczin

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CHIP-BCIS3

Study
Controlled trial of High-risk coronary Intervention with Percutaneous left ventricular unloading

IRAS no
290599

Study contact information
Name: Laura Barker
Email: l.barker2@rbht.nhs.uk

Principal investigator
Dr Vasileios Panoulas

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The ROMA Trial

Study
Randomised comparison of the clinical Outcome of single versus Multiple Arterial grafts

IRAS no
321239

Study contact information
Name: Maria Teresa Pfyl
Email: m.pfyl@rbht.nhs.uk

Principal investigator
Mr Cesare Quarto

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PANDOS

Study
Pain and opioids after surgery (PANDOS)

IRAS no
276689

Study contact information
Name: Dr Nandor Marczin
Email: N.Marczin@rbht.nhs.uk

Principal investigator
Dr Nandor Marczin

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4D Flow CMR in Lung Transplant Assessment

Study
4D Flow Cardiovascular Magnetic Resonance analysis of the right ventricle in lung transplant assessment

IRAS no
270554

Study contact information
Name: Dr Joyce Wong
Email: J.Wong@rbht.nhs.uk

Principal investigator
Dr Joyce Wong

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Statins for Improving Organ Outcome in Transplantation (SIGNET)

Study
An evaluation of the benefits of a single dose of Simvastatin given to potential organ donors declared dead by neurological criteria on outcomes in organ recipients

IRAS no
288722

Study contact information
Name: Kamal Liyanage
Email: k.liyanage@rbht.nhs.uk

Principal investigator
Dr Hatem Soliman Aboumarie & Dr Sian Jaggar

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E-CLAD UK

Study
Extracorporeal Photopheresis in the treatment of Chronic Lung Allograft Dysfunction: a randomised controlled trial

IRAS no
1005642

Study contact information
Name: Dr Martin Carby
Email: m.carby@rbht.nhs.uk

Principal investigator
Dr Martin Carby

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Experience and Concerns in Organ Procurement and Transplantation

Study
An Insight into Perioperative Practitioners' Learning Experience and Concerns when Assisting Heart and Lung Organ Procurement and Transplantation

IRAS no
324868

Study contact information
Name: Ms Yi Wang
Email: y.wang@rbht.nhs.uk

Principal investigator
Ms Yi Wang


Sentinel skin flap in lung transplant RCT

Study
Efficacy and mechanism of sentinel skin flap reduction of solid organ (lung) transplant rejection: A randomised controlled trial

IRAS no
318347

Study contact information
Name: Hayley Meyrick
Email: 

Principal investigator
Dr Anna Reed

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Lung Health Check Biomarker Study

Study
Lung Health Check Biomarker Study

IRAS no
258696

Study contact information
Name: Dr Benjamin Hunter
Email: B.Hunter@rbht.nhs.uk

Principal investigator
Professor Anand Devaraj

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Tool Placement in Pulmonary Nodule using a Robotic Bronchoscopy System

Study
A Prospective Investigation to Assess the Accurate Tool Placement in Pulmonary Nodule(s) using a Robotic
Navigational Bronchoscopy System with Adjunct Real-time Imaging

IRAS no
308868

Study contact information
Name: Professor Pallav Shah
Email: p.shah@rbht.nhs.uk

Principal investigator
Professor Pallav Shah

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The Physiotherapy Assessment of Breathing Pattern Dysfunction (PHAB)

Study
An evaluation of physiotherapy assessment: A mixed methods study to evaluate the physiotherapy assessment of Breathing Pattern Disorder

IRAS no
315897

Study contact information
Name: Lizzie Grillo
Email: l.grillo@rbht.nhs.uk

Principal investigator
Lizzie Grillo

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Microbiome and Metabolome in Healthy Volunteers (MATINEE Study)

Study
Investigating the stool and saliva microbiome and metabolome in healthy volunteers (The MATINEE Study). An observational cohort study

IRAS no
322270

Study contact information
Name: David Smith
Email: d.smith22@rbht.nhs.uk

Principal investigator
Professor Philip Molyneaux


RACE-MATE Trial

Study
A RAndomised Placebo Controlled Trial - to Explore the Efficacy and Mechanism of Action of Tezepelumab in EGPA (RACEMATE Trial)

IRAS no
1007564

Study contact information
Name: Harry Wilson-Morkeh
Email: h.wilsonmorkeh@rbht.nhs.uk

Principal investigator
Dr Pujan Patel

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